DNA is a ubiquitous ligand in nanoscience, serving multiple roles from sensing to drug delivery to controlled assembly. Our lab has a longstanding interest in how DNA binds to the surface of plasmonic nanostructures and how the plasmonic properties of the nanoparticles affect DNA behavior on the surface. Super-resolution fluorescence imaging allows us to monitor this crucial interface and uncover what is hidden.
P.A. Reinhardt, A.P. Crawford, C.A. West, G. Delong, S. Link, D.J. Masiello, K.A. Willets. “Towards Quantitative Nanothermometry Using Single-Molecule Counting.” J. Phys. Chem. B. 125, 12197 (2021).
X. Cheng, T.P. Anthony, C.A. West, Z. Hu, V. Sundaresan, A.J. McLeod, D.J. Masiello, K.A. Willets. “Plasmon heating promotes ligand reorganization on single gold nanorods.” J. Phys. Chem. Lett. 10, 1394 (2019).
K. L. Blythe and K.A. Willets. “Super-resolution imaging of fluorophore-labeled DNA bound to gold nanoparticles: a single molecule, single particle approach.” Invited feature article. J. Phys. Chem. C. 120, 803 (2016).
K.L. Blythe, E.J. Titus, K.A. Willets. “The effects of tuning fluorophore density, identity, and spacing on reconstructed images in super-resolution imaging of fluorophore-labeled gold nanorods.” J. Phys. Chem. C. 119, 28099 (2015).
E.J. Titus, K.L. Blythe, K.A. Willets. “Monte Carlo simulations of triplet-state photophysics for super-resolution imaging of fluorophore-labeled gold nanorods.” Proc. SPIE. 9554, 955403-1 (2015).
K.L. Blythe, E.J. Titus, K.A. Willets. “Comparing the accuracy of reconstructed image size in super-resolution imaging of fluorophore-labeled gold nanorods using different fit models.” J. Phys. Chem. C. 119, 19333 (2015).
K.L. Blythe, K.M. Mayer, M.L. Weber, K.A. Willets. “Ground state depletion microscopy for imaging interactions between gold nanowires and fluorophore-labeled ligands.” Phys. Chem. Chem. Phys. (Invited contribution to special themed issue on optical studies of single metal nanoparticles) 15, 4136-4145 (2013).